Essay About Melanoma
Melanoma is thought to develop in people who are young and have sun-damaged skin. People who have been diagnosed with the condition as a result of UV exposure also have genetic variances, it was found. In those with melanoma infections, genetic diversity lowers the likelihood that their DNA will be repaired (Shi et al. 69). Illness results from gene polymorphism. When the therapy is started at an early stage of growth, BRAF can be utilized to treat the condition.
Sunlight is just one of the many elements that have been linked to melanoma. The disease often responds well to treatment with the BRAF inhibitor. It leads to great anti-melanoma responses. However, the shrinkage of the initial tumors is normally not complete (Shi et al. 70). The incomplete shrinkage is noted to have a great probability of creating a progression of the disease afterward. Genetic variations also affect the effectiveness of using BRAF in treatment as well (Capaldo 25). It is important to test the hypothesis to determine the specific components of genetic variations that relate to melanoma. In addition, it is essential to define how the sunlight and age contribute to the presence of melanoma in individuals experiencing the genetic variations.
Experiment
Do biopsy of the skin of three individuals who have been diagnosed with the melanomas and one who is normal. The consent of the patients must be inquired before the biopsy is taken. The specimens should be titled by letters but not the exact names to ensure that the privacy of the participants is not violated. Take their medical histories and classify the samples as sunlight exposed or not, young, old, or even through their genetic compositions. Subject the normal skin sample to various conditions like sunlight and test for the cancers. Determine the genetic compositions of the individuals with the melanomas for defining the invariant genes that are have been assumed to cause melanoma.
Works cited
Capaldo, J. Brian, Devin Roller, Mark J. Axelrod, Alex F. Koeppel, Emanuel F. Petricoin, Craig L. Slingluff Jr…. & Stefan Bekiranov "Systems analysis of adaptive responses to MAP kinase pathway blockade in BRAF mutant melanoma." PloS one 10.9 (2015): e0138210.
Shi, Hubing, Aayoung Hong, Xiangju Kong, Richard C. Koya, Chunying Song, Gatien Moriceau … & Antoni Ribas, Georgina V. Long and Roger S. Lo "A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition." Cancer discovery 4.1 (2014): 69-79.
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